ulcer

2. An open sore on the skin or a mucous membrane that may become infected.

She had a small ulcer on her lip that made eating painful.

3. A break in the lining of the stomach or intestine, often caused by acid.

Stress and spicy food can make a stomach ulcer worse.

4. A corrupting influence or moral soreness in a group or society.

The scandal was an ulcer eating away at the company's reputation.